Metabolic Studies with<i>Trans</i>-5-Amino-3-[2-(5-Nitro-2-Furyl)Vinyl]-1,2,4-[5-¹⁴C]Oxadiazole (SQ 18,506): 1. Reductive Cleavage of the 1, 2, 4-oxadiazole ring

Abstract

1. Reductive cleavage of the oxadiazole ring of trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-[5-14C]oxadiazole (SQ 18,506-14C) has been demonstrated both enzymically and chemically.2. Oral administration of SQ 18,506-14C to humans and rat resulted in the formation of respiratory 14CO2 and the excretion of 14C-urea in the urine.3. Formation of 14CO2 was demonstrated in vitro by incubation of SQ 18,506-14C with homogenate of human or mouse liver or with milk xanthine oxidase.4. 14C-urea was isolated after reduction of SQ 18,506-14C by ferrous hydroxide.