Infection Control and Hospital Epidemiology · 2012 · 25 citations · 4 references
Case-case Control StudyDrug ResistanceIndependent Risk FactorsAntimicrobial StewardshipClinical EpidemiologyInfection ControlAnti-infective AgentsAntimicrobial ResistanceHealth SciencesVancomycin-resistant EnterococciPrior Daptomycin ExposureAntimicrobial PharmacokineticsClinical MicrobiologyEpidemiologyAntimicrobial SusceptibilityAntibioticsClinical InfectionMicrobiologyAntimicrobial PharmacodynamicsMedicine
A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.
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Genetic Basis for In Vivo Daptomycin Resistance in Enterococci
César A. Arias, Diana Panesso, Danielle M. McGrath et al. · New England Journal of Medicine · 2011 · 382 citations · Full text