Synthesis of Novel Spiro[dihydropyridine-oxindole] Compounds in Water

Abstract

An efficient one-pot synthesis of the biologically important spiro[dihydropyridine-oxindole] scaffold was accomplished simply by the reaction of isatin, 2H-indene-1,3-dione and naphthalen-2-amine in aqueous medium. The scope of this reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) in place of isatin to access the synthesis of corresponding spirocyclic derivatives.