EXPRESSION OF HEPATOCYTE GROWTH FACTOR AND ITS RECEPTOR C-MET IN ACQUIRED RENAL CYSTIC DISEASE ASSOCIATED WITH RENAL CELL CARCINOMA

Abstract

These results suggest that up-regulation of HGF and its receptor c-met may be involved in renal cyst formation and subsequent tumor transformation in patients with end stage renal disease. Increased Bcl-2 expression may promote this process through the inhibition of apoptosis.