Impairment of mitochondrial oxidative phosphorylation in the brain of aged mice

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

Christoph Richter, J W Park, B N Ames · Proceedings of the National Academy of Sciences · 1988 · 1.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

Douglas C. Wallace · Science · 1992 · 1.3K citations

Life Sciences, Genetics, Molecular Genetics +17

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

AnthonyW. Linnane, Takayuki Ozawa, S Marzuki et al. · The Lancet · 1989 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +12

DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATORY CHAIN FUNCTION: POSSIBLE FACTOR IN AGEING

Ian A. Trounce, Edward Byrne, Sangkot Marzuki · The Lancet · 1989 · 731 citations

Life Sciences, Biochemistry, Physiology +12

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

Yong Zhang, Olivier Marcillat, Cecilia Giulivi et al. · Journal of Biological Chemistry · 1990 · 714 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17