Microwave assisted one‐pot synthesis of pyrrolo[2,1‐<i>b</i>]thiazol‐6‐ones from α‐aroyl ketene‐<i>N</i>,<i>S</i>‐acetals

Abstract

Abstract magnified image α‐Aroyl ketene‐ N , S ‐acetals 3 prepared by the reaction of β‐oxothioamides 1 with phenacyl bromides 2 , underwent sequential cyclizations under microwave irradiation to afford pyrrolo[2,1‐ b ]thiazol‐6‐ones 6 in good yields. A double cyclization takes place regioselectively in one pot and variety of functionalized pyrrolo[2,1‐b]thiazol‐6‐ones were prepared by this protocol. The mode of cyclization under microwave condition is different from conventional heating. J. Heterocyclic Chem., (2010).