Concepedia

The effects of two single doses of tramadol on sleep: a randomized, cross-over trial in healthy volunteers

Bernhard Walder, Martin R. Tramèr, R. Blois

European Journal of Anaesthesiology · 2001 · 38 citations · 14 references

DOI

Abstract

In healthy volunteers, a single dose of tramadol 50 mg disturbs sleep in the night of drug application. With 100 mg, sleep is disturbed in both the night of drug application and in the subsequent night.

References

14

Sympathetic-Nerve Activity during Sleep in Normal Subjects

Virend K. Somers, Mark Eric Dyken, Allyn L. Mark et al. · New England Journal of Medicine · 1993 · 1.5K citations · Full text

Anesthesia with Abdominal Surgery Leads to Intense REM Sleep during the First Post-operative Week

R. L. Knill, Carol A. Moote, M. I. Skinner et al. · Anesthesiology · 1990 · 331 citations · Full text

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Efficacy and Safety of Tramadol Versus Morphine for Moderate and Severe Postoperative Pain With Special Regard to Respiratory Depression

Robert-Jan Houmes, Michael A. Voets, A. Verkaaik et al. · Anesthesia & Analgesia · 1992 · 299 citations

, , +20

Abuse potential and pharmacological comparison of tramadol and morphine

Kenzie L. Preston, Donald R. Jasinski, Margaret Testa · Drug and Alcohol Dependence · 1991 · 241 citations

, , +10

Contribution of monoaminergic modulation to the analgesic effect of tramadol

Jules Desmeules, Valérie Piguet, L Collart et al. · British Journal of Clinical Pharmacology · 1996 · 238 citations · Full text