Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates Ectopic<i>FoxE3</i>Expression and Disruption in Fiber Cell Differentiation

Abstract

Our findings demonstrate that the ectopic activation of downstream effectors of the hedgehog signaling pathway in the mouse lens disrupts normal fiber cell differentiation by a mechanism consistent with a sustained epithelial cellular developmental program driven by FoxE3.