Synthesis of 1-Amino-2,5-dihydro-1H-phosphole 1-Oxides and Their N-Phosphinoyl Derivatives, Bis(2,5-dihydro-1H-phosphol-1-yl)amine P,P′-Dioxides

Abstract

Depending on the molar ratio of the reactants and on the order of mixing, the reactions of a series of primary amines with 1-chloro-2,5-dihydro-1<i>H</i>-phosphole 1-oxides prepared in situ from the corresponding hydroxy-dihydrophosphole oxides afforded 1-amino-2,5-dihydro-1<i>H</i>-phosphole 1-oxides, or their <i>N</i>-phosphinoyl derivatives, bis(2,5-dihydro-1<i>H</i>-phosphol-1-yl)amine <i>P</i>,<i>P</i>′-dioxides. The latter family of P-heterocycles could also be synthesized by the reaction of 1-amino-2,5-dihydro-1<i>H</i>-phosphole oxides with chloro-dihydrophosphole oxides.