Clonidine vs. midazolam as premedication in children undergoing adeno‐tonsillectomy: A prospective, randomized, controlled clinical trial

Abstract

Rectal premedication with clonidine was associated with a significant reduction of pain in the early postoperative period compared to midazolam and was also associated with moderately increased sedation during the first 24 postoperative hours. The sedative effect of clonidine is in agreement with the unambiguous finding of a parental preference for a calm and sedated child during the first 24 postoperative hours.