High-pressure organic synthesis

Abstract

Abstract Some important problems of organic synthesis and ways to solve them by the use of hgh pressure are the topic of this paper. Three representative groups of organic reactions, cycloadditions, simple additions, and nucleophilic and electrophilic substitutions, illustrate the possibilities and usefulness of the high-pressure technique in organic synthesis. Moreover, applications of high-pressure methodology to syntheses of natural products are described. Examples are given of the influence of pressure on organic reactions in the following essential aspects: acceleration of the reaction rate, modification of regio-and stereochemistry, and changes in the reaction equilibrium.