Trapping of oxidized <scp>LDL</scp> in lysosomes of <scp>K</scp>upffer cells is a trigger for hepatic inflammation - Concepedia

Concepedia

Publication | Open Access

Trapping of oxidized <scp>LDL</scp> in lysosomes of <scp>K</scp>upffer cells is a trigger for hepatic inflammation

DOI Full Paper Access

80

Citations

22

References

2013

Year

Veerle Bieghs, Sofie M. A. Walenbergh, Tim Hendrikx, Patrick J. van Gorp, Fons Verheyen, Steven W.M. Olde Damink, Ad Masclee, Ger H. Koek, Marten H. Hofker, Christoph J. Binder,

Liver International

Abstract

These data suggest that trapping of oxLDL inside lysosomes of KCs in vivo is causally linked to increased hepatic inflammatory gene expression. Our novel observations provide new bases for prevention and treatment of NASH.

References

	Year	Citations

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