Bacterial Toxin N-Formyl-Methionyl-Leucyl-Phenylalanine Acutely Contracts Human and Rabbit Detrusor Through the Release of Eicosanoids

Abstract

Bacterial derived f-MLP contracts the detrusor through the release of eicosanoids from resident macrophages. These data suggest that bacterial activation of the resident macrophage network could participate in causing the symptoms of bacterial cystitis.