The Use and Effectiveness of Temozolomide in Children with Central Nervous System Tumours: A Survey from the Canadian Paediatric Brain Tumour Consortium

Abstract

Temozolomide is used in a variety of pediatric brain tumours, often at the time of recurrence. The lack of insight into clear indications for this agent in pediatric brain tumours-used either alone or in combination therapy-may be a result of suboptimal design of phase i and ii studies and a lack of phase iii trials in the pediatric brain tumour population.