Journal of the Chemical Society Perkin Transactions 1 · 1982 · 47 citations · 0 references
Life SciencesBotanyPharmacologyBiochemical PharmacologyPlant BiochemistryStructure-activity RelationshipsSteroid BiosynthesisSteroid StructureStructure-activity Relationship AnalysisTerpenoid BiosynthesisAdenylate Cyclase RegulationAdenylate Cyclase SignalingOrganic Reduction ReactionsPlant Functional GroupsPositive Inotropic AgentsReduction Reactions
Forskolin (1)(7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one), the major diterpenoid of Coleus forskohlii, has potent positive inotropic, antihypertensive, and adenylate cyclase stimulant properties. The reactivity of its various functional groups (1α-OH, 6β-OH, the derived 7β;-OH, 9α-OH, 11-oxo, and 14,15-double bond) has been studied through acylation, alkylation, dehydration, oxidation, and reduction reactions.