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Microwave-Assisted Addition of Pyrroles to Electron-Deficient Olefins: A Rapid Entry to<i>C</i>-Alkyl Pyrroles
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2005
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Electron-deficient OlefinsChemical EngineeringEngineeringGeneral ProcedureAlkene MetathesisApplied PhysicsCatalytic SynthesisOrganic ChemistryMicrowave-assisted AdditionMicrowave IrradiationCatalysisOrganometallic CatalysisChemistrySilica GelRapid EntrySynthetic ChemistryMicrowave Synthesis
A general procedure for the Michael addition of pyrroles with electron-deficient olefins using silica gel supported reagent under microwave irradiation, has been developed. This new method is fast, efficient, environmentally benign and solvent-free. A catalytic amount of BiCl3 is employed for moderately bulk electron-deficient olefins.