Penicillin biosynthesis: active site mapping with<scp>L</scp>-α-aminoadipoyl-(C-methyl-<scp>L</scp>-cysteinyl)-<scp>D</scp>-valine variants

Abstract

A series of structural variants of the cysteinyl moiety of the natural precursor of penicillins, δ(L-α-aminoadipoyl)-L-cysteinyl-D-valine, have been synthesised and their effectiveness as substrates for the enzyme isopenicillin N synthetase has been evaluated.