British Journal of Urology · 1985 · 21 citations · 6 references
PharmacyClinical PharmacokineticsPharmacokineticsDrug ClearanceRenal PathophysiologyRenal PharmacokineticsGlomerular FiltrationPlasma ClearanceRenal Blood FlowRenal ClearanceRenal Drug DistributionRenal Function TestsGlomerular Filtration Rate AssessmentGlomerular Filtration Rate MeasurementRenal Blood Flow MeasurementRenal Clearance AssessmentRenal Plasma ClearanceRenal Plasma Flow MeasurementSingle-sample Estimation
Thirty adult patients were investigated with 36 125I Hippuran and 40 51Cr EDTA single injection clearance studies. "Volumes of distribution" obtained from single samples have been correlated with the slope clearances and regression equations have been determined. From these equations it is possible to determine glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from single plasma samples and the method is sufficiently accurate for routine application.
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Glomerular filtration rate measurement in man by the single injection methods using 51Cr-EDTA.
C Chantler, E.S. Garnett, V. Parsons et al. · PubMed · 1969 · 438 citations
Glomerular filtration rate estimation based on a single blood sample.