Publication | Closed Access
Bripiodionen, a New Inhibitor of Human Cytomegalovirus Protease from <i>Streptomyces</i> sp. WC76599
20
Citations
6
References
1997
Year
ImmunologyAntimicrobial ChemotherapyAntiviral DrugNew InhibitorDrug ResistanceNew Natural ProductAntiviral Drug DevelopmentInhibitory ActivityCompound 1Health SciencesBioassay-guided IsolationVirologyAntibacterial AgentAntimicrobial CompoundPharmacologyClinical MicrobiologyHuman Cytomegalovirus ProteaseMicrobiologyMedicineDrug Discovery
Bripiodionen (1), a new natural product, was isolated from Streptomyces sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against human cytomegalovirus protease with an IC50 value of 30 microM.
| Year | Citations | |
|---|---|---|
Page 1
Page 1