Effect of Interleukin-3 on Responsiveness to Granulocyte-Colony-stimulating Factor in Severe Aplastic Anemia

Abstract

Brief Reports1 August 1992Effect of Interleukin-3 on Responsiveness to Granulocyte-Colony-stimulating Factor in Severe Aplastic AnemiaKlaus Geissler, MD, Christa Forstinger, MD, Peter Kalhs, MD, Paul Knöbl, MD, Peter Kier, MD, Paul Kyrle, MD, Klaus Lechner, MDKlaus Geissler, MDSearch for more papers by this author, Christa Forstinger, MDSearch for more papers by this author, Peter Kalhs, MDSearch for more papers by this author, Paul Knöbl, MDSearch for more papers by this author, Peter Kier, MDSearch for more papers by this author, Paul Kyrle, MDSearch for more papers by this author, Klaus Lechner, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-3-223 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSome patients with aplastic anemia show temporary improvements in hematopoiesis after monotherapy with hematopoietic growth factors (1-3), but those with severe cases rarely respond (4). Inadequate response in these patients is thought to be caused by a profound deficiency of hematopoietic progenitors (5). We recently reported that interleukin-3 effectively expands the pool of hematopoietic progenitors in primates, suggesting that this molecule may be used therapeutically to make hematopoiesis more responsive to late-acting cytokines (6). Pretreatment with interleukin-3 has been shown to potentiate the effects of granulocyte-macrophage colony-stimulating factor on myelopoiesis (7), of erythropoietin on erythropoiesis (8), and of interleukin-6 on...References1. Vahan-Raj S, Buescher S, Broxmeyer H, LeMaistre A, Lepe-Zuniga J, and Ventura G. Stimulation of myelopoiesis in patients with aplastic anemia by recombinant human granulocyte-macrophage colony-stimulating factor. N Engl J Med. 1988;319:1628-34. CrossrefMedlineGoogle Scholar2. Champlin R, Nimer S, Ireland P, Oette D, and Golde D. Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage colony-stimulating factor. Blood. 1989;73:694-9. CrossrefMedlineGoogle Scholar3. Antin J, Smith B, Holmes W, and Rosenthal D. Phase I/II study of recombinant human granulocyte-macrophage colony-stimulating factor in aplastic anemia and myelodysplastic syndrome. Blood. 1988; 72:705-13. CrossrefMedlineGoogle Scholar4. Nissen C, Tichelli A, Gratwohl A, Speck B, Milne A, and Gordon-Smith E. Failure of recombinant human granulocyte-macrophage colony-stimulating factor therapy in aplastic anemia patients with very severe neutropenia. Blood. 1988;72:2045-7. CrossrefMedlineGoogle Scholar5. Ganser A, Lindemann A, Seipelt G, Ottmann O, Eder M, and Falk S. Effects of recombinant human interleukin-3 in aplastic anemia. Blood. 1990;76:1287-92. CrossrefMedlineGoogle Scholar6. Geissler K, Valent P, Mayer P, Liehl E, Hinterberger W, and Lechner K. Recombinant human interleukin-3 expands the pool of circulating hematopoietic progenitor cells in primates-synergism with recombinant human granulocyte/macrophage colony-stimulating factor. Blood. 1990;75:2305-10. CrossrefMedlineGoogle Scholar7. Donahue R, Seehra J, Metzger M, Lefebvre D, Rock B, and Carbone S. Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science. 1988;241:1820-3. CrossrefMedlineGoogle Scholar8. Umemura T, Al-Khatti A, Donahue R, Papayannopoulou T, and Stamatoyannopoulos G. Effects of interleukin-3 and erythropoietin on in vivo erythropoiesis and F-cell formation in primates. Blood. 1989; 74:1571-6. CrossrefMedlineGoogle Scholar9. Geissler K, Valent P, Bettelheim P, Sillaber C, Wagner B, and Kyrle P. In vivo synergism of recombinant human interleukin-3 and recombinant human interleukin-6 on thrombopoiesis in primates. Blood. 1992;79:1155-60. CrossrefMedlineGoogle Scholar10. Zsebo K, Williams D, Geissler E, Broudy V, Martin F, and Atkins H. Stem cell factor is encoded at the S1 locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell. 1990;63:213-24. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Klaus Geissler, MD; Christa Forstinger, MD; Peter Kalhs, MD; Paul Knöbl, MD; Peter Kier, MD; Paul Kyrle, MD; Klaus Lechner, MDFrom the University of Vienna, Vienna, Austria. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombopoietic Factors in Chronic Bone Marrow Failure States: The Platelet Problem RevisitedPathophysiology and treatment of aplastic anemiaInterleukin-3: Promises and PerspectivesCLINICAL ASPECTS OF APLASTIC ANEMIARecombinant human interleukin-3 in refractory severe aplastic anaemia: a phase I/II trialA phase I/II trial of recombinant human interleukin-6 in patients with aplastic anaemiaInterleukin-3Pharmacodynamics of daily subcutaneous recombinant human interleukin-3 in normal volunteers*Treatment of refractory severe aplastic anemia with granulocyte colony stimulating factor and interleukin 3Present and future clinical relevance of interleukin 3Granulocyte-Macrophage colony stimulating factor and interleukin 3: Target cells and kinetics of response in vivoGranulocyte colony-stimulating factor (rh G-CSF) as an adjunct to interferon alpha therapy of neutropenic patients with hairy cell leukemiaCytokine serum levels during treatment with high-dose recombinant human IL-3 in a patient with severe aplastic anemiaInterleukin 3 and interleukin 3/gm‐csf combination therapy ‐ clinical implicationsMultilineage response in aplastic anemia patients following long‐term administration of filgrastim (recombinant human granulocyte colony stimulating factor)Cytokine-Cytokine Interactions in the Context of Cytokine NetworkingCytokines and biological response modifiers in the treatment of infection 1 August 1992Volume 117, Issue 3Page: 223-225KeywordsAplastic anemiaCytokinesErythropoiesisErythropoietinGranulocyte macrophage colony stimulating factorHematopoiesisHematopoietic growth factors ePublished: 1 December 2008 Issue Published: 1 August 1992 PDF downloadLoading ...