Biopolymer-Released Dexamethasone Prevents Tumor Necrosis Factor α-Induced Loss of Auditory Hair Cells In Vitro

Abstract

Polymer-eluted DXMb retains its otoprotection capabilities in our in vitro test system of TNFalpha-challenged organ of Corti explants by altering the pattern of gene expression to favor survival of TNFalpha-exposed HCs. These results, although in vitro, support the application of polymer containing DXMb to electrode arrays for the conservation of hearing during cochlear implantation.