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Simple, Facile and Highly Selective Tetrahydropyranylation of Alcohols Using Silica Chloride
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2001
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Room TemperatureChemical EngineeringEnantioselective SynthesisEngineeringOrganic ChemistryCatalysisStereoselective SynthesisChemistrySymmetric DiolsSilica ChlorideAsymmetric CatalysisSynthetic ChemistryHighly Selective TetrahydropyranylationBiomolecular Engineering
A simple and efficient process for tetrahydropyranylation of alcohols has been developed by reacting with dihydropyran at room temperature in presence of catalytic amount of silica chloride. The process is highly selective for monoprotection of the hydroxyl groups of symmetric diols.