Polymerase chain reaction: amplification of DNA from fixed tissue

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

Randall K. Saiki, Stephen J. Scharf, Fred Faloona et al. · Science · 1985 · 9K citations

Medicine, Genetics, Molecular Genetics +17

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

Randall K. Saiki, Teodorica L. Bugawan, Glenn T. Horn et al. · Nature · 1986 · 1.8K citations

Life Sciences, Genetics, Molecular Genetics +14

Purification of DNA from formaldehyde fixed and paraffin embedded human tissue

Susan Goelz, Stanley R. Hamilton, Bert Vogelstein · Biochemical and Biophysical Research Communications · 1985 · 811 citations

Medicine, Molecular Biology, Pathology +9

Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation.

Y Kan, A M Dozy · Proceedings of the National Academy of Sciences · 1978 · 801 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17