MedicinePharmacologyPharmacotherapyHypersensitivityPoisoning DiagnosisPoisoning ManagementAdverse Drug ReactionsAdverse EffectsAcute Poisoning PresentationClinical Manifestations Of PoisoningClinical Signs Of PoisoningPenicillin ResistancePoisoningRapid Improvement Events
BMEIsH dose to 100,000 units six-hourly was quite dramatic and a rapid improvement set in. Case 2 received 250,000 units three-hourly. After the first dose there was a sharp rise of temperature from 100 to 1040 F. (37.8 to 400 C.), the patient became violent and abusive, and he had to be given a sedative. Thereafter he improved rapidly and the temperature was normal by next morning. Suchett- Kaye drew attention to a reaction resembling the Jarisch-Herxheimer reaction which may occur at the beginning of treatment of Weil's disease with penicillin.