Protein kinase C-dependent inhibition of BK_Cacurrent in rat aorta smooth muscle cells following γ-irradiation

Abstract

The results suggest that irradiation-evoked inhibition of the BK(Ca) current in aortic VSMC is mediated by PKC. Taken together, our data indicate that one of the mechanisms leading to elevation of vascular tone and related arterial hypertension development under ionising irradiation impact is a PKC-mediated inhibition of BK(Ca) channels in VSMC.