Clinical Infectious Diseases · 2003 · 86 citations · 48 references
Public HealthMaternal HealthObstetricsMaternal-fetal MedicineObstetric ComplicationsReproductive MedicineDrug-susceptible Tuberculosis TreatmentMaternal Medical Complications In PregnancyPregnancyPrenatal CareTuberculosis CareTuberculosis In PregnancyChronic Tuberculosis LesionsDrug-resistant Tuberculosis In PregnancyMultidrug-resistant Tuberculosis TreatmentObstetric Complications Of TuberculosisPerinatal Transmission Of TuberculosisPregnancy Outcomes In TuberculosisTuberculosis DiagnosticsTuberculosis Treatment During Pregnancy
Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem affecting women of childbearing age. Little is known, however, about the safety of the drugs used to treat MDR-TB during pregnancy. We describe 7 patients who were treated for MDR-TB during pregnancy. These patients had chronic tuberculosis that had caused extensive parenchymal damage and had high-grade resistance to antituberculous drugs. All patients received individualized antituberculous therapy prior to delivery of healthy term infants. Neither obstetrical complications nor perinatal transmission of MDB-TB was observed. One patient experienced treatment failure, and another abandoned therapy. The other 5 patients are currently cured or in treatment and have culture-negative status. In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy.
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