Single Nucleotide Polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 Are Associated With Heaviness of Smoking in Women in Northeastern Ontario, Canada

Abstract

SNPs from 2 distinct variant groups were significantly associated with heaviness of smoking in this homogeneous population of women with high smoking rates, and this study supports the interpretation that there are different mechanisms of nicotine addiction involving both increasing and decreasing risk.