SHORT‐TERM STUDY OF THE EFFECT OF PHENACETIN, PHENAZONE AND AMIDOPYRINE ON THE RAT KIDNEY

Abstract

Phenacetin has been implicated in kidney damage in man (Spuhler & Zollinger, 1953); however, the number of cases of kidney damage from phenacetin consumption reported from Switzerland, Germany and Scandinavia is greater than that reported from Australia and the United States, though the average consumption of phenacetin per head is similar in all these countries The reported incidence of " analgesic nephritis " is also low in Great Britain, where the consumption of phenacetin is not less than in the other countries (Prescott, 1965).