Tandem sp³ C–H Functionlization/Decarboxylation of 2-Alkylazaarenes with Coumarin-3-carboxylic Acids

Abstract

The catalyst-free sp(3) C-H functionalization of 2-alkylazaarenes has been achieved in the reaction with (thio)coumarin-3-carboxylic acids. Followed by a tandem decarboxylation, this method provides facile synthesis of biologically important azaarene-substituted 3,4-dihydro(thio)coumarins in a single step in high yields.