Efficient Consecutive Four‐Component Synthesis of 5‐Acylpyrid‐2‐ones Initiated by Copper‐Free Alkynylation

Abstract

Abstract A one‐pot, consecutive, four‐component synthesis of 5‐acylpyrid‐2‐ones initiated by Pd/cataCXium ® ABn catalysis proceeds under mild reaction conditions and in good yields, with a broad scope of three points of diversity. This sequence is superior to the initially proposed Pd/Cu‐catalyzed version because all four components can be employed in close to stoichiometric amounts.