CHEMO- AND STEREOSELECTIVE ADDITION OF DIORGANYLPHOSPHINE OXIDES TO α,β-ETHYLENIC ALDEHYDES

Abstract

Secondary phosphine oxides (R1)2P(O)H 1–3 react with α,β-ethylenic aldehydes R2CH=CHC(O)H 4–6 under mild conditions (THF, 22–42°C) to form chemo- and stereoselectively hydroxyethenylphosphine oxides (R1)2P(O)CH(OH)CH=CHR2 (E) 7a–h in high yield.