Application of Asymmetric Ylide Cyclopropanation in the Total Synthesis of Halicholactone

Abstract

Efficient shortcut: The use of the well-known cyclopropanation reaction provided facile access to the main fragment of halicholactone with excellent enantioselectivity and diastereoselectivity in only five steps (see scheme). This enabled the total synthesis of halicholactone with an overall yield of 11.2 % in the shortest synthetic route so far.