Electroretinogram Changes in Acute Quinine Poisoning

Abstract

An experimental model, using rabbits, for acute quinine toxicity is presented. Electroretinogram changes are shown to occur within minutes of the ingestion of 0.5 gm/kg. They consist of increase in a-wave negativity and b-wave depression, which return to normal within 24 hours. These changes should not be due to any action on the ganglion cell and call for a revision of current thinking on quinine toxicity.