Practical Asymmetric Synthesis of (<i>R</i>)-Fluoxetine Hydrochloride Catalyzed by (2<i>S</i>, 4<i>S</i>)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1-(<i>N</i>-methylcarbamoyl)pyrrolidine-Rhodium Complex<sup>1</sup> - Concepedia

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Practical Asymmetric Synthesis of (<i>R</i>)-Fluoxetine Hydrochloride Catalyzed by (2<i>S</i>, 4<i>S</i>)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1-(<i>N</i>-methylcarbamoyl)pyrrolidine-Rhodium Complex<sup>1</sup>

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References

1991

Year

Shunji Sakuraba, Kazuo Achiwa

Medicinal ChemistryEngineeringNatural SciencesDiversity-oriented SynthesisOrganic ChemistryPractical Asymmetric SynthesisHydrochloride CatalyzedOrganometallic CatalysisChemistryHalogenationAsymmetric Catalysisß-Amino Ketone DerivativesSynthetic ChemistryBiomolecular EngineeringAsymmetric Hydrogenation

Abstract

The title complex, (2S,4S)-MCCPM-Rh(I) complex, was found to be an efficient catalyst for asymmetric hydrogenation of ß-amino ketone derivatives leading to a practical asymmetric synthesis of (R)-Fluoxetine [N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine] hydrochloride.