Formulation and evaluation of buccal film of Ivabradine hydrochloride for the treatment of stable angina pectoris

Abstract

The present study indicated enormous potential of mucoadhesive buccal patches containing Ivabradine for systemic delivery with an added advantage of circumventing hepatic first pass metabolism. Further work is recommended to support its efficacy claims by long term pharmacokinetic and pharmacodynamic studies in human beings.