Upregulated TWIK‐related acid‐sensitive K⁺channel‐2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy

Abstract

Our findings suggest that elevated TASK-2 immunoreactivity in neurons may contribute to rapid adaptive responses (presumably for extracellular alkalinization), which result in hyperpolarization and regulate seizure activity. In contrast, upregulated TASK-2 immunoreactivity in perivascular regions may be involved in abnormalities of blood flow regulation or brain-blood barrier impairment. These changes may contribute to acquisition of the properties of the epileptic hippocampus.