Physicochemical and Biological Evaluation of P792, a Rapid-Clearance Blood-Pool Agent for Magnetic Resonance Imaging

Abstract

The relaxivity of P792 at clinical field is very high for a monogadolinium complex without protein binding. The pharmacokinetic and biodistribution profiles are consistent with those of a rapid-clearance blood-pool agent. Its initial safety profile is satisfactory. Experimental and clinical studies are underway to confirm the potential of P792 in MRI.