Beyond Picomolar Affinities: Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to Proteins

Abstract

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTBeyond Picomolar Affinities: Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to ProteinsAdam J. T. Smith†, Xiyun Zhang†, Andrew G. Leach‡, and K. N. Houk*†View Author Information Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, and AstraZeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K.* To whom correspondence should be addressed. Phone: [phone]. Fax: [phone]. E-mail: [email protected]†University of California, Los Angeles.‡AstraZeneca Pharmaceuticals.Cite this: J. Med. Chem. 2009, 52, 2, 225–233Publication Date (Web):November 21, 2008Publication History Received30 April 2008Published online21 November 2008Published inissue 22 January 2009https://pubs.acs.org/doi/10.1021/jm800498ehttps://doi.org/10.1021/jm800498ereview-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views9521Altmetric-Citations150LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inhibitors,Noncovalent interactions,Peptides and proteins,Receptors,Screening assays Get e-Alerts