The Stability of 5,6-Dihydrofluorouracil in Plasma and the Consequences for Its Analysis - Concepedia

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The Stability of 5,6-Dihydrofluorouracil in Plasma and the Consequences for Its Analysis

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1987

Year

N. van den Bosch, O. Driessen, E. A. van der Velde, Cornelis Erkelens

Therapeutic Drug Monitoring

Cold Atmospheric PlasmaRoom Temperature5,6-Dihydrofluorouracil KeptFluorous SynthesisPlasma StabilityPlasma SamplesChemistryNonthermal PlasmaBiophysics

Abstract

This study shows that 5,6-dihydrofluorouracil kept in plasma at room temperature deteriorates in time. Preservation is gained by low temperature and low pH of plasma samples. Therefore, plasma samples should be buffered and frozen immediately after being obtained, and thawing should proceed to 5 degrees C only.