Neurology · 1981 · 43 citations · 0 references
MedicineNeurologyNeuroscienceNeurocritical CareNeurological Critical CareResuscitationCardiac Arrest ManagementCardiopulmonary ResuscitationFluid ResuscitationNeurologic PrognosticationPost-cardiac Arrest CarePost-resuscitation CareNeurologic DiagnosticsNeurologic FunctionNeurologic Outcome AssessmentNeurologic Outcomes After Cardiac ArrestNeurologic Prognostication After Cardiac ArrestNeurological PrognosticationOut-of-hospital Cardiac ArrestPost-cardiac Arrest Neurologic Prognostication
In patients resuscitated from out-of-hospital cardiac arrest, neurologic outcome was compared with creatine kinase isoenzyme BB activity (CKBB) in cerebrospinal fluid (CSF) in 20 patients and in serum in 52 patients. CSF CKBB was 2 units per liter or less in patients with complete neurologic recovery but was significantly elevated in patients without neurologic recovery (mean, 55 units per liter) or with incomplete neurologic recovery (mean, 7 units per liter). Serum CKBB was detected more than 6 hours after cardiac arrest in only 4% of patients with complete neurologic but in all patients without neurologic recovery. These results demonstrate a relationship between CSF and serum CKBB and neurologic outcome after cardiac arrest.