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THE RELATIVE ANTIBACTERIAL EFFICIENCY OF IgM, IgG AND IgA FROM PIG COLOSTRUM
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1971
Year
Laboratory ImmunologyHumoral ResponseImmunologyVeterinary MicrobiologyInfection ControlAntimicrobial ResistanceAutoimmune DiseaseE. Coli 0111AutoimmunityHumoral ImmunityAntibacterial AgentPorcine DiseaseHost-microbe InteractionClinical MicrobiologyImmunoglobulin ClassesSummary IgaAntimicrobial SusceptibilityMucosal ImmunologyAnimal ScienceImmunoglobulin EMicrobiologyMedicine
Summary IgA, IgG and IgM have been isolated and purified from colostrum of two sows immunized with E. coli 0111. The three immunoglobulin classes have been tested for their direct bactericidal action with complement and for their opsonic and intracellular killing activity in a test using mouse peritoneal phagocytes. IgA showed only marginal bactericidal action with complement in contrast to IgM and IgG. However, the specific IgA antibody was found to be more active in promoting phagocytosis and intracellular killing than either IgM or IgG. These observations suggest that IgA may play an important role in intestinal immunity.