EXPRESSION AND LOCALIZATION OF HYPOXIA MARKERS IN PROSTATE CANCER; PROGNOSTIC IMPLICATIONS AFTER RADICAL PROSTATECTOMY

Abstract

This study confirms the upregulation of proteins involved in the HIF-1alpha hypoxia pathway in prostate cancer cells, indicative of a hypoxic tumor state. Importantly, we report the identification of 2 novel markers, GLUT1 and prolyl-4-hydroxylases 1, with prognostic significance for patients undergoing radical prostatectomy.