Catalytic Hydrogenolysis of 1,1-Difluoro-2-phenyl- and 1,1-Difluoro-3-methyl-2-phenylcyclopropane

Abstract

Abstract The title compounds were hydrogenolyzd over PdO or Raney nickel. The C2–C3 bond of the cyclopropane ring underwent cleavage exclusively over the both catalysts. The contribution of the fluorine substituent to the lengthening and weakening the C2–C3 bond of the cyclopropane ring seems to become a dominant factor in the regioselectivity.