Clinical and Experimental Pharmacology and Physiology · 1990 · 22 citations · 13 references
Life SciencesEndocrinologyPhysiologyHormone BiochemistryMetabolic RegulationSignal TransductionAdrenal EndocrinologyAdrenal HormonesAdrenal Steroid HormonesAdrenal SteroidogenesisEndocrine PhysiologySteroidogenesis RegulationAldosterone PhysiologyAldosterone RegulationAldosterone SignalingInositol Phosphate SignalingInositol Triphosphate SignalingInositol Trisphosphate SignalingPhosphatidylinositol 4, 5-BisphosphatePhosphatidylinositol Metabolism
1. Endothelin (ET), vasopressin (VP) and angiotensin II (AII) all stimulate aldosterone production in adrenal glomerulosa cells but the response to AII is greater than that to either ET or VP. 2. Total inositol phosphate responses to AII and ET were similar but the response to VP was lower. 3. Cytosolic free Ca2+ responses to AII were higher than to either of the other peptides. 4. Metabolism of 145IP3 was different under stimulation by the three different peptides. 5. Adrenal glomerulosa cells can distinguish between three different agonists which stimulate phosphatidylinositol turnover and produce a selective response to each peptide.
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