1f:T47a,The maxillary sinuses of 20 patients (median age, 15 years) with cystic fibrosis were examined with ultrasound, radiography, and transantral sinus aspiration (14 bilateral and six unilateral for a total of 34 aspirates). The sinus aspirations were performed with careful sterile techniques, and the material that was recovered was cultured quantitatively for both aerobic and anaerobic bacteria. Nineteen (95%) of the 20 patients had at least one positive (greater than or equal to 10(4) colony-forming units/ml) culture of sinus aspirate. The organisms most commonly recovered from the sinus aspirates were Pseudomonas aeruginosa (13), Haemophilus influenzae (10), streptococci (five), and anaerobes (five). There was no association between the bacterial species recovered from the sinus and the predominant bacterial species in the nasopharyngeal, throat, or sputum culture. Although most patients had been chronically receiving therapeutic oral doses of antimicrobial agents, bacteria sensitive to the antimicrobial agents that the patient had been taking (excluding P. aeruginosa) were recovered from the sinuses of nine of these 10 patients.20:T41a,Since Andersen's¹original description of cystic fibrosis (CF) of the pancreas, its various manifestations have been widely studied.^2-17Recognition of and interest in the various clinical expressions of CF have resulted from such factors as (a) the increasing longevity of patients with more successful management, (b) heightened medical awareness of the disease, and (c) the availability of more sensitive diagnostic tests permitting the identification of mild or unusual cases. We have been impressed by the high incidence of abnormal roentgenograms of the sinuses in these individuals without symptoms of sinus disease. The purpose of this report is to present this observation and to discuss its significance. This observation has been mentioned only briefly by previous authors.^18-21

Materials and Methods

All pediatric cases of CF seen in the Children's Treatment Center of the National Jewish Hospital and in the Department of Pediatrics, University of Colorado Medical Center were

	Year	Citations

References