High Frequency of<i>SERPINA6</i>Polymorphisms that Reduce Plasma Corticosteroid-Binding Globulin Activity in Chinese Subjects

Abstract

Defects in CBG A51V production explain why plasma CBG levels in individuals heterozygous for this variant are approximately 50% lower than normal. The high frequency of CBG A51V will allow clinical consequences of CBG deficiencies to be assessed for the first time in large patient populations.