Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · 2006 · 10 citations · 0 references
MedicinePathologyRadiologyDiagnostic ImagingDiagnostic RadiologyPulmonologyComputed TomographyDiffuse Lung DiseaseInterstitial Lung DiseaseMedical ImagingPulmonary Function AssessmentPulmonary PathologyDisease Extent QuantificationFibrosis QuantificationIdiopathic Pulmonary Fibrosis ImagingLung Function TestingLung Volume QuantificationMultidetector Computed TomographyPulmonary Function ChangesQuantitative Lung Imaging
Idiopathic pulmonary fibrosis (IPF, also known as Idiopathic Usual Interstitial Pneumontis, pathologically) is a progressive diffuse lung disease which has a median survival rate of less than four years with a prevalence of 15-20/100,000 in the United States. Global function changes are measured by pulmonary function tests and the diagnosis and extent of pulmonary structural changes are typically assessed by acquiring two-dimensional high resolution CT (HRCT) images. The acquisition and analysis of volumetric high resolution Multi-Detector CT (MDCT) images with nearly isotropic pixels offers the potential to measure both lung function and structure. This paper presents a new approach to three dimensional lung image analysis and classification of normal and abnormal structures in lungs with IPF.