Influx of Neutrophils into the Airway Lumen at 4 h after Segmental Allergen Challenge in Asthma

Abstract

Neutrophil chemotactic activity is increased in BAL fluid at 4 h after segmental allergen challenge. We suggest that apart from IgE-mediated mast cell degranulation, additional local factors in the airways determine the degree of IL-8 increase and neutrophil influx.