Gadolinium Neutron Capture Therapy (GdNCT) of Melanoma Cells and Solid Tumors With the Magnetic Resonance Imaging Contrast Agent Gadobutrol

Abstract

In vitro and in vivo studies showed a therapeutic benefit with the neutral Gd complex and suggest Gd-containing magnetic resonance contrast media are potential candidates for neutron capture therapy. The Gd dose used in the irradiation experiments was four times the presently accepted high dose in clinical magnetic resonance imaging.