Eosinophil Response to Alum Adjuvants: Involvement of T Cells in Non-Antigen-Dependent Mechanisms

Abstract

SummaryAluminium hydroxide attracted eosinophils to injection sites in the absence of specific antigenic stimulation. This was markedly reduced by depletion of T cells. These observations suggest that eosinophilia caused by a nonimmunological stimulus required the presence of T cells, and imply that these lymphocytes were'involved in reactions in which specific antigen recognition played no role.